1. (Noun): The real physical matter of which a person or thing consists
2. (Noun): What a communication that is about something is about
3. (Noun): The choicest or most essential or most vital part of some idea or experience
1. DNA is the substance of our genes
2. The gist of the prosecutor's argument
3. The heart and soul of the Republican Party
4. The nub of the story
1. Substance
2. Subject matter
3. Message
4. Content
5. Kernel
6. Essence
7. Nitty-gritty
8. Center
9. Heart and soul
10. Centre
11. Sum
12. Heart
13. Marrow
14. Core
15. Gist
16. Inwardness
17. Meat
18. Pith
19. Nub
1. Component
2. Component part
3. Constituent
4. Part
5. Portion
6. Matter
7. Communication
8. Cognitive content
9. Mental object
10. Content
1. Protoplasm
2. Chemistry
3. Living substance
4. Essence
5. Body substance
6. Volatile
7. Medium
8. Chemical element
9. Material
10. Mixture
11. Fluid
12. Activator
13. Atom
14. Substrate
15. Stuff
16. Phlogiston
17. Element
18. Acknowledgement
19. Subject
20. Meaninglessness
21. Disapproval
22. Body
23. Counselling
24. Discourtesy
25. Offer
26. Tale
27. View
28. Humor
29. Meaning
30. Latent content
31. Publicity
32. Info
33. Postulation
34. Proposal
35. Counsel
36. Narrative
37. Dedication
38. Garbage
39. Commitment
40. Disrespect
41. Parenthesis
42. Hokum
43. Entry
44. Aside
45. Offering
46. Topic
47. Insertion
48. Commendation
49. Signification
50. Drivel
51. Request
52. Import
53. Wittiness
54. Divagation
55. Nonsense
56. Sensationalism
57. Corker
58. Digression
59. Humour
60. Statement
61. Theme
62. Memorial
63. Excursus
64. Direction
65. Respects
66. Shocker
67. Wit
68. Reminder
69. Counseling
70. Approval
71. Refusal
72. Packaging
73. Opinion
74. Significance
75. Witticism
76. Interpolation
77. Guidance
78. Instruction
79. Petition
80. Narration
81. Promotional material
82. Nonsensicality
83. Information
84. Submission
85. Bunk
86. Acknowledgment
87. Story
88. Promotion
89. Quintessence
90. Quiddity
91. Haecceity
92. Bare bones
93. Hypostasis
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